Rodent carcinogenesis bioassay with oxisuran, a selective immunosuppressive agent

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Rodent carcinogenesis bioassay with oxisuran, a selective immunosuppressive agent.

The carcinogenic potential of oxisuran, a synthetic immunosuppressive agent, was studied for 80 weeks and 104 weeks in mice and rats, respectively. Groups of 50 mice and 70 rats of each sex received oxisuran at doses of 600, 240, and 40 mg/kg/day as dietary admixtures over the entire experimental period. Adequate survival rates allowed accurate statistical analysis of diagnosed neoplasia. Incre...

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ژورنال

عنوان ژورنال: Toxicology

سال: 1983

ISSN: 0300-483X

DOI: 10.1016/0300-483x(83)90102-6